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°æ»ó´ëÇб³ ÀÚ¿¬°úÇÐ´ë »ý¸í°úÇкΠ(352µ¿ 523È£)
Àü È­   : +82-55-772-1360
ÆÑ ½º   :+82-55-772-1359
ÀüÀÚ¿ìÆí: kwlee@gnu.ac.kr

 

¿¬±¸ºÐ¾ß
(Research)

  • °è»ê»ý¹°ÇÐ/ºÐÀڸ𵨸µ(Computational Biology/Molecular Modeling): ÄÄÇ»ÅÍ ¸ðÀǽÇÇèÀ» ÀÌ¿ëÇÑ ´Ü¹éÁú-¸®°£µå/´Ü¹éÁú-´Ü¹éÁú »óÈ£ÀÛ¿ë ¿¬±¸ (ºÐÀÚµ¿·ÂÇÐ/ºÐÀÚµµÅ· ¸ðÀǽÇÇèµî)
  • ÄÄÇ»Å͸¦ ÀÌ¿ëÇÑ ½Å¾à¼³°è(Computer-Aided Drug Design): 2D/3D QSAR, Ligand/Receptor Based Drug Design
  • »ý¹°Á¤º¸ÇÐ(Bioinformatics)/ÀΰøÁö´É-±â°èÇнÀ(Machine Learning)/ºòµ¥ÀÌÅÍ: ÀΰøÁö´É ±â¹Ý ½Å¾à¼³°è±â¹ý ¿¬±¸, È­ÇÕ¹° ºòµ¥ÀÌÅÍ Ã³¸®¹× ºÐ¼®
  • ÇзÂ
    (Education)

  • ¼­¿ï´ëÇб³ ÀÚ¿¬´ëÇÐ È­Çаú Çлç
  • ¼­¿ï´ëÇб³ ÀÚ¿¬´ëÇÐ È­Çаú ¼®»ç (¹°¸®È­ÇÐ)
  • ¼­¿ï´ëÇб³ ÀÚ¿¬´ëÇÐ È­Çаú ¹Ú»ç (ÀÌ·Ð/°è»êÈ­ÇÐ)
  • ÁÖ¿ä°æ·Â
    (Experiences)

  • Univ. of California at Berkeley È­Çаú (¹Ú»çÈÄ¿¬±¸¿ø)
  • Univ. of Houston, »ý¹°»ýÈ­Çаú (¹Ú»çÈÄ¿¬±¸¿ø/¿¬±¸±³¼ö)
  • ¹Ì±¹ ÈÞ½ºÅÏ VisiGen Biotechnologies, Inc. (¼±ÀÓ¿¬±¸¿ø)
  • °æ»ó´ëÇб³ (»ýÈ­Çаú) »ý¸íÈ­ÇкΠÁ¶±³¼ö/ºÎ±³¼ö/±³¼ö
  • °æ»ó´ëÇб³ ¾àÇдëÇÐ ÃßÁø´ÜÀå(ÇÐÀå)
  • °æ»ó´ëÇб³ ½ÄÀǾàÇ° ´ëÇпøÀå
  • °æ»ó´ëÇб³ ´ë¿ÜÇù·Â ºÎº»ºÎÀå / ÀÚ¿¬´ëºÎÇÐÀå
  • Çѱ¹»ý¸íÁ¤º¸ÇÐȸ(KSBi) ȸÀå 2017-2018
  • BK21 (4´Ü°è) ¹ÙÀÌ¿ÀÀÇ·áºòµ¥ÀÌÅÍ »ç¾÷´ÜÀå 2020-2027


    ÇмúÈ°µ¿:
  • TBC/BIOINFO 2018 ´ëȸÀå (http://kobic.kr/tbc-bioinfo2018/)
  • GIW2017(Genome Informatics Workshop/BIOINFO 2017) ´ëȸÀå (http://kobic.kr/giw-bioinfo2017)
  • Asia Hub for e-Drug Discovery (AHeDD2018) Á¶Á÷À§¿øÀå (http://ahedd.asia)
  • NanoBio-Seoul 2008 ±¹Á¦ÇмúȸÀÇ Á¶Á÷À§¿ø (http://www.nanobio-seoul2008.org)
  • Bioinfo2009 ±¹Á¦ÇмúȸÀÇ Á¶Á÷À§¿ø (http://www.ksbsb.or.kr)
  • 2011 ¾Æ½Ã¾ÆÅÂÆò¾ç »ý¹°Á¤º¸ÇÐȸ (APBC2011) Á¶Á÷À§¿øÀå (http://sysbio.kribb.re.kr/APBC2011)
  • 2011 °Ô³ð±¹Á¦Á¤º¸ÇÐȸ (GIW2011) Á¶Á÷À§¿ø (http://www.kobic.re.kr/giw2011)
  • ±¹Á¦³í¹® Interdisciplinary Bio Central (IBC) ÆíÁýÀ§¿ø (http://www.ibc7.org)


  • ÇÐȸ:
  • ±¹Á¦°è»ê»ý¹°ÇÐȸ (ISCB) ȸ¿ø (http://www.iscb.org)
  • ¹Ì±¹È­ÇÐȸ (ACS) ȸ¿ø (http://www.acs.org)
  • Çѱ¹»ý¸íÁ¤º¸ÇÐȸ(KSBi) ȸ¿ø (http://www.ksbi.or.kr)
  • ´ëÇÑÈ­ÇÐȸ (KCS) ȸ¿ø (http://www.kcsnet.or.kr)
  • Çѱ¹À¯ÀüüÇÐȸ (KOGO) ȸ¿ø (http://www.kogo.or.kr)
  • Çѱ¹»ý¹°¹°¸®ÇÐȸ (KBS) ȸ¿ø (http://www.biophysics.or.kr)


  • [ÇÐȸȰµ¿: ¹Ì±¹È­ÇÐȸ, ´ëÇÑÈ­ÇÐȸ, Çѱ¹»ý¹°Á¤º¸ÇÐȸ, Çѱ¹»ý¹°¹°¸®ÇÐȸ, ´Ü¹éÁú¿¬±¸È¸, ´ë»çü¿¬±¸È¸,..]


     

    ¿¬±¸¾÷Àû
    (Achievements)

    [¿¬±¸³í¹®/Research Papers (´ëÇ¥³í¹®/Selected List)]

    • K. Bharatham, N. Bharatham, K. W. Lee, "Molecular Dynamics Simulation Study of PTP1B with Allosteric Inhibitor and its Application in Receptor Based Pharmacophore Modeling." Journal of Computer-Aided Molecular Design (2008, in press). [ PDF ]

    • K. Bharatham, N. Bharatham, K. W. Lee, "Binding Mode Analyses and Pharmacophore Model Development for Sulfonamide Chalcone Derivatives, a New Class of a-Glucosidase Inhibitors." Journal of Molecular Graphics and Modelling 26 1202-1212 (2008.05). [ PDF ] (Co-First Authors)

    • Y. Zhai, M. H. Nawaz, E. Kirkbride, K. W. Lee, J. M. Briggs, S. A. Martinis "Modulation of Substrate Specificity within the Amino Acid Editing Site of Leucyl-tRNA Synthetase." Biochemistry 46(11), 3331-3337 (2007.03). [ PDF ]

    • S. B. Rho, K. W. Lee, S.-H. Lee, K. Park, J.-H. Lee " Identification of Apotosis-Related Residues in Human Thymosin b-10 by Mutational Analysis and Computational Modeling." J. Biol. Chem. 280(30) 34003-34007 (2005.10). [ PDF ] (Co-First Authors)

    • B. A. Mulder, P. Yu, S. Anaya, K. W. Lee, A. Nguyen, J. Murphy, R. Willson, J. M. Briggs, X. Gao, S. H. Hardin "Nucleotide Modification at the gamma-phosphate Leads to the Improved Fidelity of HIV-1 Reverse Transcriptase." Nucleic Acids Res. 33(15) 4865-4873 (2005.09). [ PDF ]

    • A. Brigo, K. W. Lee, G. I. Mustata, J. M. Briggs "Comparison of Multiple Molecular Dynamics Trajectories Calculated for the Drug-Resistant HIV-1 Integrase T66I/M154I Catalytic Domain" Biophysical J. 88(5), 3072-3082 (2005.05). [ PDF ]

    • J. Deng, K. W. Lee, T. Sanchez, M. Cui, N. Neamati, J. M. Briggs "Dynamic Receptor-Based Pharmacophore Model Development and its Application in Designing Novel HIV-1 Integrase Inhibitors. " J. Med. Chem. 48(5), 1496-1505 (2005.03). [ PDF ]

    • K. W. Lee , J. M. Briggs "Molecular Modeling Study for the Editing Activity of  E. coli Leucyl-tRNA Synthetase: Two Amino Acid Binding Sites in the CP1 domain." PROTEINS: Structure, Function and Bioinformatics 54(4) 693-704 (2004.03). [ PDF ]

    [ Àüü¸ñ·Ïº¸±â(Full List) ]


    [¹Ì±¹Æ¯Çã/U.S. Patent]

    • 1. A. Volkov, C. Colbert, I. Pan, A. Kraltcheva, M. Reddy, N. Battulga, M. Rea, K. W. Lee, B. Mulder, S. Hardin "A Method for Analyzing Fluorescent Resonance Energy Transfer Event at the Single Molecular Level." US Patent

    • 2. S. A. Martinis, J. M. Briggs, R. S. Mursinna,K. W. Lee, T. L. Lincecum, C. Davis, M. Cui, A. M. Williams, J. A. Speidel, Y. Zhai "Method and Composition for Leucyl-tRNA Synthetases and Derivatives thereof That Activate and Aminoacylate Non-Leucine Amino Acids to tRNA Adaptor Molecules." US Patent

     


    [ÇмúȸÀÇ ¹ßÇ¥/Poster Presentation (ÀϺÎ/Selected)]

    • P. Lazar, K. W. Lee, "Effect of Ionic Strength on RNA-binding Protein Complex Conformation - A Molecular Dynamics Simulation Approach." in The 101th Annual Meeting of Korean Chemical Society, KINTEX, Goyang City, Kyeonggi-Do, Korea, Apr. 17-28, 2008.

    • S. Kim, Y. Lee, C. Park, A. Baek, K. W. Lee, "Analysis of Four Domains Motion of A. aeolicus Argonaute Protein with siRNA using Molecular Dynamics Simulations." in The 101th Annual Meeting of Korean Chemical Society, KINTEX, Goyang City, Kyeonggi-Do, Korea, Apr. 17-28, 2008.

    • P. Gajendrarao, N. Krishnamoorthy, S. Y. Lee, K. W. Lee, ¡°Molecular Dynamics Simulations Study on Human Cytochrome P450 3A4 with Substrates: Mutation Effect of L293P.¡± in The International Conference on Bioinformatics and Drug Dicovery, University of Hyderabad, India, Dec. 20-22, 2007.

    • K. Bharatham, N. Bharatham, J. D. Bahk, K. W. Lee,¡°Receptor Based Dynamic Pharmacophore Model for PTP1B Allosteric Site.¡± in The 8th International Conference of Korean Society for Bioinformatics(KSBI), KRIBB, Daejeon City, Korea, Nov. 15-16, 2007.

    • Y. Lee, N. Krishnamoorthy, K. W. Lee, ¡°Linking of Two Key Domains in AtTDX using Computer Modelling Methods.¡± in The 99th Annual Meeting of Korean Chemical Society, COEX, Seoul, Korea, Apr. 19-20, 2007.

    • N. Bharatham, K. Bharatham, K. W. Lee, "Methionyl-tRNA Synthetase, an Unexploited Antibacterial Target Inhibitor Design.", in The 97th Annual Meeting of Korean Chemical Society, KINTEX, Goyang City, Kyeonggi-Do, Korea, Apr. 20-21, 2006.

    • Y. Lee, N. Bharatham, K. Bharatham, E. Lee, K. W. Lee, "Docking Studies of Pharmacophore Model Based Adenosine Kinase Inhibitors.", in The 97th Annual Meeting of Korean Chemical Society, KINTEX, Goyang City, Kyeonggi-Do, Korea, Apr. 20-21, 2006.

    • K. Navaneethakrishnan, L. Shui, K. W. Lee, "In silico Simulations of E. coli HslVU to Explore B. subtilis CodWX Structure." , in The 97th Annual Meeting of Korean Chemical Society, KINTEX, Goyang City, Kyeonggi-Do, Korea, Apr. 20-21, 2006.

    • K. Bharatham, N. Bharatham, K. W. Lee, "Novel Inhibitor Design for P56 LCK using Analog and Structure Based Drug Design.", in BIOINFO2005, joint international conference of AASBi, InCoB and KSBI, BEXCO, Busan, KOREA, Sep. 22-24, 2005.

    • N. Bharatham, K. Bharatham, S.Vadivelan, K. W. Lee, "Computer-Aided Inhibitor Design for Methionyl-tRNA Synthetase." in BIOINFO2005, joint international conference of AASBi, InCoB and KSBI, BEXCO, Busan, KOREA, Sep. 22-24, 2005. (Outstanding Poster Award)

    • K. Bharatham, N. Bharatham, K. W. Lee, "Innovative Chemical Database Design for Drug Discovery." in Annual Meeting of Korean Society of Life Science , Gyeongsang National University, Jinju, KOREA, April 8-9, 2005.

    • N. Bharatham, K. Bharatham, K. W. Lee, "Quantitative Structure-Activity Relationships (QSAR) and Molecular Docking Studies of P56 LCK Inhibitors." in Annual Meeting of Korean Society of Life Science , Gyeongsang National University, Jinju, KOREA, April 8-9, 2005.

    [ Àüü¸ñ·Ïº¸±â(Full List) ]



    [ÃÊû°­¿¬/Invited Talks (ÀϺÎ/Selected)]

    • À¯ÇѾçÇà Áß¾Ó¿¬±¸¼Ò Research Center of Yuhan (Pharmaceutical) Corporation, Yongin, Korea (August 29, 2008)

    • ¿¬¼¼´ëÇб³ ºÐÀÚ¼³°è¿¬±¸¼Ò Bioinformatics and Molecular Design and Research Center at Yonsei University, Seoul, Korea (August 21, 2008)

    • ¼÷¸í¿©´ë ½Å¾à¼³°è¿öÅ©¼¥ Computer-Aided Drug Design Workshop at Sukmyeong Wamans University, Seoul, Korea (June 13, 2008)

    • Çѱ¹»ý¹°Á¤º¸ÇÐȸ The 8th International Conference of Korean Society for Bioinformatics BIOINFO2007 at KRIBB, Daejeon, Korea (November 15, 2007)

    • ¹Ì±¹ ¹ÌÁ¶¸®´ëÇÐ »ý¸í°úÇкΠThe 2nd GNU-MU(Missouri University) Joint Symposium at Missouri University, Columbia, MO, USA (October 3, 2007)

    • °æÈñ´ëÇб³ È­Çаú KyungHee University, Department of Chemistry, Seoul, KOREA, January 18, 2006

    • ÃæºÏ´ëÇб³ È­Çаú Chungbuk National University, Department of Chemistry, Chungju, KOREA, October 13, 2005

    • ¼øõ´ëÇб³ È­Çаú Sunchon National University, Department of Chemistry, Sunchon, KOREA, April 28, 2005

    • ¿µ³²´ëÇб³ »ý¸í°øÇкΠYeungnam University, School of Biotechnology, Gyeongsan, KOREA, April 8, 2005

    • ¼­¿ï´ëÇб³ È­ÇкΠSeoul National University, Department of Chemistry, Seoul, KOREA, March 24, 2005

    • ¼­¿ï´ëÇб³ ¾àÇдëÇÐ Seoul National University, College of Pharmacy, Seoul, KOREA, October 25, 2004

    • ¼­¿ï´ëÇб³ »ý¸í°úÇкΠSeoul National University, School of Life Science, Seoul, KOREA, October 25, 2004

    • °­¿ø´ëÇб³ Ç÷°ü¿¬±¸¼¾ÅÍ Kangwon National University, Vascular System Research Center (VSRC), Chunchon, KOREA, June 22, 2004

    • ±¤ÁÖ °úÇбâ¼ú¿ø »ý¸í°úÇаú GIST (Gwangju Instititue of Science ans Technology), Department of Life Science, Gwangju, KOREA, June 7, 2004

    • ¿¬¼¼´ëÇб³ »ý¸í°øÇаú Yonsei University, Department of Biotechnolgy, Seoul, KOREA, June 4, 2004

    [ Àüü¸ñ·Ïº¸±â(Full List) ]