[ CV in English(영문판) ]

이근우 교수


경상대학교 자연과학대 생화학과 (352동 523호)
전 화   : +82-55-772-1360
팩 스   :+82-55-772-1359
전자우편: kwlee@gnu.ac.kr

 

연구분야
(Research)

  • 계산생물학/분자모델링(Computational Biology/Molecular Modeling): 컴퓨터 모의실험을 이용한 단백질-리간드/단백질-단백질 상호작용 연구 (분자동력학/분자도킹 모의실험등)
  • 컴퓨터를 이용한 분자(신약)설계(Computer-Aided Drug Design): 2D/3D QSAR, Ligand/Receptor Based Drug Design
  • 생물정보학(Bioinformatics)/시스템생물학(Systems Biology): 생물정보분석 및 데이터베이스(DB)구축, 단백질/유전자 네트워크 구성및 분석
  • 학력
    (Education)

  • 서울대학교 자연대학 화학과 이학사
  • 서울대학교 자연대학 화학과 석사 (물리화학)
  • 서울대학교 자연대학 화학과 박사 (이론/계산화학)
  • 주요경력
    (Experiences)

  • Univ. of California at Berkeley 화학과 (박사후연구원)
  • Univ. of Houston, 생물생화학과 (박사후연구원/연구교수)
  • 미국 휴스턴 VisiGen Biotechnologies, Inc. (선임연구원)
  • 경상대학교 생화학과 조교수/부교수
  • 경상대학교 약학대학 추진단장
  • 경상대학교 식의약품 대학원장
  • 경상대학교 대외협력 부본부장


    학술활동:
  • 한국생물정보시스템생물학회(KSBSB) 이사 2005-
  • NanoBio-Seoul 2008 국제학술회의 조직위원 (http://www.nanobio-seoul2008.org)
  • Bioinfo2009 국제학술회의 조직위원 (http://www.ksbsb.or.kr)
  • 2011 아시아태평양 생물정보학회 (APBC2011) 조직위원장 (http://sysbio.kribb.re.kr/APBC2011)
  • 2011 게놈국제정보학회 (GIW2011) 조직위원 (http://www.kobic.re.kr/giw2011)
  • 국제논문 Interdisciplinary Bio Central (IBC) 편집위원 (http://www.ibc7.org)


  • 학회:
  • 국제계산생물학회 (ISCB) 회원 (http://www.iscb.org)
  • 미국화학회 (ACS) 회원 (http://www.acs.org)
  • 한국생물정보시스템생물학회(KSBSB) 회원 (http://www.ksbsb.or.kr)
  • 대한화학회 (KCS) 회원 (http://www.kcsnet.or.kr)
  • 한국유전체학회 (KOGO) 회원 (http://www.kogo.or.kr)
  • 한국생물물리학회 (KBS) 회원 (http://www.biophysics.or.kr)


  • [학회활동: 미국화학회, 대한화학회, 한국생물정보학회, 한국생물물리학회, 단백질연구회, 대사체연구회,..]


     

    연구업적
    (Achievements)

    [연구논문/Research Papers (대표논문/Selected List)]

    • K. Bharatham, N. Bharatham, K. W. Lee, "Molecular Dynamics Simulation Study of PTP1B with Allosteric Inhibitor and its Application in Receptor Based Pharmacophore Modeling." Journal of Computer-Aided Molecular Design (2008, in press). [ PDF ]

    • K. Bharatham, N. Bharatham, K. W. Lee, "Binding Mode Analyses and Pharmacophore Model Development for Sulfonamide Chalcone Derivatives, a New Class of a-Glucosidase Inhibitors." Journal of Molecular Graphics and Modelling 26 1202-1212 (2008.05). [ PDF ] (Co-First Authors)

    • Y. Zhai, M. H. Nawaz, E. Kirkbride, K. W. Lee, J. M. Briggs, S. A. Martinis "Modulation of Substrate Specificity within the Amino Acid Editing Site of Leucyl-tRNA Synthetase." Biochemistry 46(11), 3331-3337 (2007.03). [ PDF ]

    • S. B. Rho, K. W. Lee, S.-H. Lee, K. Park, J.-H. Lee " Identification of Apotosis-Related Residues in Human Thymosin b-10 by Mutational Analysis and Computational Modeling." J. Biol. Chem. 280(30) 34003-34007 (2005.10). [ PDF ] (Co-First Authors)

    • B. A. Mulder, P. Yu, S. Anaya, K. W. Lee, A. Nguyen, J. Murphy, R. Willson, J. M. Briggs, X. Gao, S. H. Hardin "Nucleotide Modification at the gamma-phosphate Leads to the Improved Fidelity of HIV-1 Reverse Transcriptase." Nucleic Acids Res. 33(15) 4865-4873 (2005.09). [ PDF ]

    • A. Brigo, K. W. Lee, G. I. Mustata, J. M. Briggs "Comparison of Multiple Molecular Dynamics Trajectories Calculated for the Drug-Resistant HIV-1 Integrase T66I/M154I Catalytic Domain" Biophysical J. 88(5), 3072-3082 (2005.05). [ PDF ]

    • J. Deng, K. W. Lee, T. Sanchez, M. Cui, N. Neamati, J. M. Briggs "Dynamic Receptor-Based Pharmacophore Model Development and its Application in Designing Novel HIV-1 Integrase Inhibitors. " J. Med. Chem. 48(5), 1496-1505 (2005.03). [ PDF ]

    • K. W. Lee , J. M. Briggs "Molecular Modeling Study for the Editing Activity of  E. coli Leucyl-tRNA Synthetase: Two Amino Acid Binding Sites in the CP1 domain." PROTEINS: Structure, Function and Bioinformatics 54(4) 693-704 (2004.03). [ PDF ]

    [ 전체목록보기(Full List) ]


    [미국특허/U.S. Patent]

    • 1. A. Volkov, C. Colbert, I. Pan, A. Kraltcheva, M. Reddy, N. Battulga, M. Rea, K. W. Lee, B. Mulder, S. Hardin "A Method for Analyzing Fluorescent Resonance Energy Transfer Event at the Single Molecular Level." US Patent

    • 2. S. A. Martinis, J. M. Briggs, R. S. Mursinna,K. W. Lee, T. L. Lincecum, C. Davis, M. Cui, A. M. Williams, J. A. Speidel, Y. Zhai "Method and Composition for Leucyl-tRNA Synthetases and Derivatives thereof That Activate and Aminoacylate Non-Leucine Amino Acids to tRNA Adaptor Molecules." US Patent

     


    [학술회의 발표/Poster Presentation (일부/Selected)]

    • P. Lazar, K. W. Lee, "Effect of Ionic Strength on RNA-binding Protein Complex Conformation - A Molecular Dynamics Simulation Approach." in The 101th Annual Meeting of Korean Chemical Society, KINTEX, Goyang City, Kyeonggi-Do, Korea, Apr. 17-28, 2008.

    • S. Kim, Y. Lee, C. Park, A. Baek, K. W. Lee, "Analysis of Four Domains Motion of A. aeolicus Argonaute Protein with siRNA using Molecular Dynamics Simulations." in The 101th Annual Meeting of Korean Chemical Society, KINTEX, Goyang City, Kyeonggi-Do, Korea, Apr. 17-28, 2008.

    • P. Gajendrarao, N. Krishnamoorthy, S. Y. Lee, K. W. Lee, “Molecular Dynamics Simulations Study on Human Cytochrome P450 3A4 with Substrates: Mutation Effect of L293P.” in The International Conference on Bioinformatics and Drug Dicovery, University of Hyderabad, India, Dec. 20-22, 2007.

    • K. Bharatham, N. Bharatham, J. D. Bahk, K. W. Lee,“Receptor Based Dynamic Pharmacophore Model for PTP1B Allosteric Site.” in The 8th International Conference of Korean Society for Bioinformatics(KSBI), KRIBB, Daejeon City, Korea, Nov. 15-16, 2007.

    • Y. Lee, N. Krishnamoorthy, K. W. Lee, “Linking of Two Key Domains in AtTDX using Computer Modelling Methods.” in The 99th Annual Meeting of Korean Chemical Society, COEX, Seoul, Korea, Apr. 19-20, 2007.

    • N. Bharatham, K. Bharatham, K. W. Lee, "Methionyl-tRNA Synthetase, an Unexploited Antibacterial Target Inhibitor Design.", in The 97th Annual Meeting of Korean Chemical Society, KINTEX, Goyang City, Kyeonggi-Do, Korea, Apr. 20-21, 2006.

    • Y. Lee, N. Bharatham, K. Bharatham, E. Lee, K. W. Lee, "Docking Studies of Pharmacophore Model Based Adenosine Kinase Inhibitors.", in The 97th Annual Meeting of Korean Chemical Society, KINTEX, Goyang City, Kyeonggi-Do, Korea, Apr. 20-21, 2006.

    • K. Navaneethakrishnan, L. Shui, K. W. Lee, "In silico Simulations of E. coli HslVU to Explore B. subtilis CodWX Structure." , in The 97th Annual Meeting of Korean Chemical Society, KINTEX, Goyang City, Kyeonggi-Do, Korea, Apr. 20-21, 2006.

    • K. Bharatham, N. Bharatham, K. W. Lee, "Novel Inhibitor Design for P56 LCK using Analog and Structure Based Drug Design.", in BIOINFO2005, joint international conference of AASBi, InCoB and KSBI, BEXCO, Busan, KOREA, Sep. 22-24, 2005.

    • N. Bharatham, K. Bharatham, S.Vadivelan, K. W. Lee, "Computer-Aided Inhibitor Design for Methionyl-tRNA Synthetase." in BIOINFO2005, joint international conference of AASBi, InCoB and KSBI, BEXCO, Busan, KOREA, Sep. 22-24, 2005. (Outstanding Poster Award)

    • K. Bharatham, N. Bharatham, K. W. Lee, "Innovative Chemical Database Design for Drug Discovery." in Annual Meeting of Korean Society of Life Science , Gyeongsang National University, Jinju, KOREA, April 8-9, 2005.

    • N. Bharatham, K. Bharatham, K. W. Lee, "Quantitative Structure-Activity Relationships (QSAR) and Molecular Docking Studies of P56 LCK Inhibitors." in Annual Meeting of Korean Society of Life Science , Gyeongsang National University, Jinju, KOREA, April 8-9, 2005.

    [ 전체목록보기(Full List) ]



    [초청강연/Invited Talks (일부/Selected)]

    • 유한양행 중앙연구소 Research Center of Yuhan (Pharmaceutical) Corporation, Yongin, Korea (August 29, 2008)

    • 연세대학교 분자설계연구소 Bioinformatics and Molecular Design and Research Center at Yonsei University, Seoul, Korea (August 21, 2008)

    • 숙명여대 신약설계워크샵 Computer-Aided Drug Design Workshop at Sukmyeong Wamans University, Seoul, Korea (June 13, 2008)

    • 한국생물정보학회 The 8th International Conference of Korean Society for Bioinformatics BIOINFO2007 at KRIBB, Daejeon, Korea (November 15, 2007)

    • 미국 미조리대학 생명과학부 The 2nd GNU-MU(Missouri University) Joint Symposium at Missouri University, Columbia, MO, USA (October 3, 2007)

    • 경희대학교 화학과 KyungHee University, Department of Chemistry, Seoul, KOREA, January 18, 2006

    • 충북대학교 화학과 Chungbuk National University, Department of Chemistry, Chungju, KOREA, October 13, 2005

    • 순천대학교 화학과 Sunchon National University, Department of Chemistry, Sunchon, KOREA, April 28, 2005

    • 영남대학교 생명공학부 Yeungnam University, School of Biotechnology, Gyeongsan, KOREA, April 8, 2005

    • 서울대학교 화학부 Seoul National University, Department of Chemistry, Seoul, KOREA, March 24, 2005

    • 서울대학교 약학대학 Seoul National University, College of Pharmacy, Seoul, KOREA, October 25, 2004

    • 서울대학교 생명과학부 Seoul National University, School of Life Science, Seoul, KOREA, October 25, 2004

    • 강원대학교 혈관연구센터 Kangwon National University, Vascular System Research Center (VSRC), Chunchon, KOREA, June 22, 2004

    • 광주 과학기술원 생명과학과 GIST (Gwangju Instititue of Science ans Technology), Department of Life Science, Gwangju, KOREA, June 7, 2004

    • 연세대학교 생명공학과 Yonsei University, Department of Biotechnolgy, Seoul, KOREA, June 4, 2004

    [ 전체목록보기(Full List) ]